GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs10789475 | chr1:46304177 | CCDC163P | chr1:45960581-45965646:- | -0.36 | -6.71 | 6.92E-11 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs10789481 | chr1:46383583 | CCDC163P | chr1:45960581-45965646:- | -0.36 | -6.64 | 1.1E-10 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs10789487 | chr1:46420221 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs7112513 | 1 | rs10790172 | chr11:116927740 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -5.02 | 7.78E-7 | Protein quantitative trait loci |
| BLCA | cis | rs6547741 | 1 | rs1080060 | chr2:27768808 | C2orf16 | chr2:27799389-27805588:+ | 0.22 | 3.83 | 0.000152 | Oral cavity cancer |
| BLCA | cis | rs10935120 | 1 | rs10804632 | chr3:134294501 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.52 | 3.83E-13 | Height |
| BLCA | cis | rs2243480 | 1 | rs10807701 | chr7:65724686 | CCT6P1 | chr7:65216092-65228661:+ | -0.33 | -4.52 | 8.25E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs10807702 | chr7:65767843 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.4 | 1.42E-5 | Diabetic kidney disease |
| BLCA | cis | rs881375 | 1 | rs10818480 | chr9:123643170 | LOC253039 | chr9:123605320-123616644:+ | -0.33 | -5.77 | 1.67E-8 | Rheumatoid arthritis |
| BLCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | CRAT | chr9:131857075-131873070:- | 0.25 | 4.53 | 7.83E-6 | Blood metabolite ratios |
| BLCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | SH3GLB2 | chr9:131770314-131790579:- | -0.16 | -4.74 | 3.06E-6 | Blood metabolite ratios |
| BLCA | cis | rs10819861 | 1 | rs10819861 | chr9:98867813 | C9orf130 | chr9:98568372-98638259:- | -0.27 | -4.62 | 5.16E-6 | Electrocardiographic traits |
| BLCA | cis | rs10819861 | 1 | rs10819861 | chr9:98867813 | ZNF367 | chr9:99148227-99180669:- | -0.16 | -4.39 | 1.45E-5 | Electrocardiographic traits |
| BLCA | cis | rs12220238 | 1 | rs10824075 | chr10:75880254 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.62 | 5.36E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs10824076 | chr10:75886956 | ADK | chr10:75910965-76469059:+ | 0.28 | 4.46 | 1.09E-5 | Soluble interleukin-2 receptor subunit alpha |